Functional outcome of patients undergoing open rotator cuff repair

Background: Rotator cuff tears are a common source of shoulder pain. The incidence of rotator cuff damage increases with age and is most frequently due to degeneration of the tendon rather than injury from sports or trauma. Rotator cuff tear can be treated arthroscopically, arthroscopically assisted (mini-open) or by an open procedure. Because of the technical demands of arthroscopic repair many surgeons consider open repair for the treatment of rotator cuff tears. This study was done to evaluate the functional outcome of shoulder after open rotator cuff repair.Methods: 26 patients with partial and complete rotator cuff tears underwent open rotator cuff repair and acromioplasty. Cases were followed up at 3 months and 6 months intervals and shoulder function was assessed using Constant-Murley scoring system and compared with the preoperative scores and analyzed using SPSS software.Results: Mean preoperative constant score was 33.95±7.545 while the mean constant score at 6 months post-surgery was 79.83±8.51 which was highly significant according to paired t test. The difference between preoperative, 3 months and 6 months constant scores of complete and partial tear patients was found to be statistically significant.Conclusions: There was highly significant increase in Constant-Murley score after 6 months in patients treated by open rotator cuff repair. Open repair still stands as an effective treatment for rotator cuff tears and doing acromioplasty during the procedure adds to better outcome after surgery

Eremophila goodwinii F. Muell.

https://thekeep.eiu.edu/herbarium_specimens_byname/21547/thumbnail.jp

Application of computer vision techniques to measure cavitation bubble volume and cavitating tip vortex diameter.

In present paper application of computer vision techniques to propeller cavitation experiments is presented. These techniques are widely adopted in many different environments and therefore they are well documented. They are also attractive from an economic point of view, due to relative low cost of the hardware involved. Nevertheless their application to study propeller behavior in cavitation tunnel is not straightforward, because of the nonstandard environment. However the adoption of these techniques may open a wide field of investigation and can result in a deepening of knowledge in propeller cavitation phenomena. In particular, obtained data can be linked to connected topics, such as propeller radiated noise or pressure signature, providing a better understanding on the sources of these effects, and invaluable information for validation of computer simulations. Present paper traces a possible path to develop an experimental technique, covering theoretical points as well as data analysis strategies and other practical aspects. All techniques are presented through practical application, thus making clearer their points of strength and their shortcomings. Besides achieved results, possible improvements and future developments are outlined.http://deepblue.lib.umich.edu/bitstream/2027.42/84235/1/CAV2009-final35.pd

LA SEMPLIFICAZIONE DEI PROCEDIMENTI DALLA PROSPETTIVA DELL'EFFICIENZA

L\u2019obiettivo della presente indagine \ue8 analizzare la relazione fra semplificazione dei processi civili ed efficienza della giustizia. Qualsiasi Stato moderno e democratico deve assicurare l\u2019amministrazione della giustizia ai soggetti che lo compongono e questa giustizia deve essere effettiva ed efficiente, pertanto l\u2019efficienza \ue8 un parametro importante nella valutazione di un sistema giudiziario. Parallelamente, un sistema giudiziario dovrebbe respingere le forme procedurali che siano incapaci di assicurare una protezione effettiva dei diritti individuali. Questi due aspetti devono essere messi in connessione fra loro con attenzione, perch\ue9 la semplificazione del diritto processuale \ue8 strettamente legata a un fine specifico, dato dalla massima efficienza perseguibile in un dato contesto. Perci\uf2, la ricerca si focalizza dapprima sul concetto di efficienza (cosa rende efficiente un processo?), cercando di scegliere fra due posizioni: un\u2019efficienza fondata sulla durata e un\u2019efficienza basata sulla qualit\ue0. Successivamente, la semplificazione del processo viene collocata nell\u2019ecosistema di riferimento, costituito dalla tipologia di efficienza prescelta (nel nostro caso, quella fondata sulla qualit\ue0 del risultato). In questa seconda parte della ricerca giungeremo a comprendere se semplificare significhi soltanto (o principalmente) escludere determinate regole processuali oppure se un processo semplificato possa nascere anche dal rafforzamento di alcuni aspetti della procedura stessa.This dissertation aims at exploring the relationship between simplified civil proceedings and the efficiency of justice. Any modern and democratic State shall provide justice to people and this justice must be effective and efficient, therefore the efficiency is an important parameter for the evaluation of a judicial system. At the same time, a judicial system should avoid any type of procedure which fails to assure an effective protection of individual rights. Simplification and efficiency must be carefully connected, because simplification of civil procedure is closely linked to the target of the maximum efficiency reachable. Thus, the work focuses first on the research question \uab what makes a trial efficient? \ubb, setting the alternative between a \u201cduration-based\u201d efficiency and a \u201cquality-based\u201d efficiency. Then, having found in favour of the quality-based one, the simplification of civil proceedings is placed in the environment created by the chosen type of efficiency. This second part of the research casts light on whether simplifying means just \u2013 or mainly \u2013 excluding certain procedural activities or if a simplified proceeding can be made also by strengthening some aspects of the procedure itself

A lower bound for interval routing in general networks

Includes bibliographical references (p. 11).At head of title: Computer science publication.Cover title.published_or_final_versio

The paradigm of norgestimate: a third-generation testosterone-derivative progestin with a peripheral anti-androgenic activity and the lowest risk of venous thromboembolism

Introduction: Norgestimate (NGM) is a testosterone derivative with peculiar receptor activities. Areas covered: This is a narrative review of the available data on the pharmacotherapy of NGM in combined hormonal contraceptives (CHCs) in terms of contraceptive efficacy, venous thromboembolism (VTE) risk, safety, tolerability and bleeding patterns. A comprehensive literature review was conducted in August 2020 using PubMed with the keyword ‘norgestimate’. Expert Opinion: NGM shows a mild estrogenic activity associated with anti-mineralocorticoid and anti-androgenic properties, largely responsible for the cardiovascular safety profile. The anti-androgenic property depends on the androgen receptor (AR) nuclear translocation (AR trafficking and its subnuclear distribution), the inhibition of 5α-reductase activity (it possesses higher activity compared to other available progestins), and the increase on sexual hormone binding globulin (SHBG) levels if combined with an estrogenic counterpart. NGM is one of the molecules that best modulates the power of ethinyl-estradiol on the thromboembolic risk, being associated with the lowest VTE risk between different CHCs. NGM has the advantage of retaining peripheral anti-androgenic activity, demonstrated by the impact on lipid and glucose metabolism, and it should be preferred if compared with other similar progestins of the same class of risk which are much more androgenic, such as levonorgestrel

Comparison of experimental and numerical sloshing loads in partially filled tanks

Sloshing phenomenon consists in the movement of liquids inside partially filled tanks, whichgenerates dynamic loads on the tank structure. Resulting impact pressures are of great importance in assessingstructural strength, and their correct evaluation still represents a challenge for the designer due to the highnonlinearities involved, with complex free surface deformations, violent impact phenomena and influence of airtrapping. In the present paper a set of two-dimensional cases for which experimental results are available areconsidered to assess merits and shortcomings of different numerical methods for sloshing evaluation, namely twocommercial RANS solvers (FLOW-3D and LS-DYNA), and two own developed methods (Smoothed ParticleHydrodynamics and RANS). Impact pressures at different critical locations and global moment induced by watermotion for a partially filled tank with rectangular section having a rolling motion have been evaluated and resultsare compared with experiments

Leggere le Indicazioni. Riflessioni e proposte per la scuola dell'infanzia

Il volume presenta il testo delle indicazioni nazionali per il curricolo della scuola dell'infanzia e del primo ciclo d'istruzione, pubblicato in forma ufficiale dal Ministero dell'Istruzione nel 2013, e ne propone un commento per quanto riguarda la parte relativa alla scuola dell'infanzia, mettendo a fuoco alcune tematiche cruciali: l'idea di scuola, di relazione educativa, di contesto, di continuità, di attività professional

Antimicrobial Peptides Human Beta-Defensin-2 and -3 Protect the Gut During Candida albicans Infections Enhancing the Intestinal Barrier Integrity: In Vitro Study

The intestinal mucosa is composed of a monolayer of epithelial cells, which is highly polarized and firmly united to each other thanks to the presence of proteins complexes, called Tight junctions (TJs). Alteration of the mucus layer and TJs causes an increase in intestinal permeability, which can lead to a microbial translocation and systemic disorders. Candida albicans, in addition to its role of commensal, is an opportunistic pathogen responsible for disseminated candidiasis, especially in immunocompromised subjects where the dysbiosis leads to damage of the intestinal mucosal barrier. In this work, we used a line of intestinal epithelial cells able to stably express the genes that encodes human beta defensin-2 (HBD-2) and -3 (HBD-3) to monitor the invasion of C. albicans in vitro. Defensins are a group of antimicrobial peptides (AMPs) found in different living organisms, and are involved in the first line of defense in the innate immune response against pathogens. The results obtained show that the presence of antimicrobial peptides improves the expression of TJs and increases the Trans Epithelial Electrical Resistence value. In addition, the invasive ability of C. albicans in transfected cells is significantly reduced, as well as the expression levels of genes involved in the apoptotic pathway. Through the study of interaction between antimicrobial peptides and microbiota we will be able in the future to better understand the mechanisms by which they exert the host defense function against intestinal pathogens